[Download] "Transfusion of Ipscs-Derived Leukocytes to Kill Cancer (Report)" by Jiang Cui, Ying Gao, Guodong Yuan, Ti-Fei Li ~ eBook PDF Kindle ePub Free

eBook details

Title: Transfusion of Ipscs-Derived Leukocytes to Kill Cancer (Report)
Author : Jiang Cui, Ying Gao, Guodong Yuan, Ti-Fei Li
Release Date : January 01, 2010
Genre: Health & Fitness,Books,Health, Mind & Body,
Pages : * pages
Size : 61 KB

Description

1. Introduction 60 years ago, Chester Southam injected healthy people and cancer patients with Hela cells, and found that healthy human beings are resistant to cancer cells, the ability of which was lost in cancer patients [1]. The important factors that lead to the loss of innate immunity during cancer progression include the failure of leukocytes (white blood cells) in killing cancer cells and the fusion of cancer cell and leukocyte, which results in the metastasis of cancer cells [2]. In recent years, a spontaneous cancer-resistant mice line was found, whose resistance is mediated by rapid infiltration of leukocytes and some other cells with innate immunity [3]. In these mice, the killing of injected cancer cells was completed by the migration of leukocytes to the cancer cells-injected site, the identification/recognition of specific antigens on the surface of cancer cells, as well as the release of cancer cell-killing substances, the first two steps of which do not exist in normal mice lines [3]. Additionally, aging leads to the reduction of this resistance ability, while repeated challenge with cancer cell injection can enhance the resistance during ageing periods. It is thus conceivable that the failed or weakened resistance of innate immunity cells, especially leukocytes, contribute to the cancer progress in patients.